Glomerular Pathology

Glomerular Pathology in Patients with HIV Infection

Advances in the pathology of glomerular diseases.

Glomerular injury can be caused by numerous insults including hemodynamics, infections and immunity, hereditary and metabolic diseases, and toxicity. Basic and translational experimental studies in combination with clinical research in patients with renal disease have advanced our understanding of the etiology and pathogenesis of many forms of glomerulonephritis. This new knowledge has facilita...

Color Atlas of Kidney Biopsy: Pathology of Glomerular Diseases

In the last section, the newer neuropeptides, the endorphins, and the gutand brain-associated peptides are introduced. Dr. Crapo concludes, "There is then, in this astounding labyrinth of chemical messengers, a certain hope for the future-if we can only rise to the adventure and press forward with the exciting research task at hand." Although this is not a textbook of hormones, nor is it intend...

Four danger response programs determine glomerular and tubulointerstitial kidney pathology

Renal biopsies commonly display tissue remodeling with a combination of many different findings. In contrast to trauma, kidney remodeling largely results from intrinsic responses, but why? Distinct danger response programs were positively selected throughout evolution to survive traumatic injuries and to regenerate tissue defects. These are: (1) clotting to avoid major bleeding, (2) immunity to...

Podocyte Pathology and Nephropathy – Sphingolipids in Glomerular Diseases

Sphingolipids are components of the lipid rafts in plasma membranes, which are important for proper function of podocytes, a key element of the glomerular filtration barrier. Research revealed an essential role of sphingolipids and sphingolipid metabolites in glomerular disorders of genetic and non-genetic origin. The discovery that glucocerebrosides accumulate in Gaucher disease in glomerular ...